St John of the Ladder Orthodox Church is centrally located in the Greater Greenville Area near the intersection of US 25S and I-185 (the ‘Southern Connector’), and can be accessed via Interstates 85, 185, 385 and US 25.

Traveling I-85 Southbound/SC 291 (Pleasantburg Drive)
(from Charlotte/Spartanburg/Eastside)

Exit 46B and continue south on SC 291 (Pleasantburg Drive)
This eventually turns into US 25 South (toward Greenwood SC and Augusta GA).
Left on Ashmore Bridge Rd (approximately 5 miles from I-85, just before you reach I-185, CVS on the corner)
Right on Augusta Arbor Way (at the first intersection)
St John is one block on the left

Traveling I-85 Northbound
(from Atlanta/Anderson/Easley)

Exit 42 onto I-185 South (the 'Southern Connector') toward Columbia
Exit 7 onto US 25 and turn north (left) toward downtown Greenville
Right on Ashmore Bridge Rd (at the first light beyond the interstate, CVS on the corner)
Right on Augusta Arbor Way (at the first intersection)
St John is one block on the left

Traveling I-85 Northbound
(alternate route without using I-185 which is a toll road)

Exit 44 onto US 25 South (Whitehorse Road).

Turn Right onto US 25 South toward Greenwood SC and Augusta GA

US 25 (Whitehorse Rd) turns right at its intersection with SC 291 (Pleasantburg Drive)
Continue South on US 25 for approximately 3 miles
Left on Ashmore Bridge Rd (just before you reach I-185, CVS on the corner)
Right on Augusta Arbor Way (at the first intersection)
St John is one block on the left

Traveling I-385 Northbound
(from Columbia via I-26/Laurens/Fountain Inn)

Exit onto I-185 North (the 'Southern Connector') toward Atlanta
Exit 7A onto US 25 North toward downtown Greenville
Right on Ashmore Bridge Rd (at the first light beyond the interstate, CVS on the corner)
Right on Augusta Arbor Way (at the first intersection)
St John is one block on the left

Traveling US 25 South (Whitehorse Rd)
(from Asheville/Hendersonville/Travelers Rest/Westside)

Traveling South (toward Greenwood and Augusta GA) on US 25 (Whitehorse Rd),
US 25 (Whitehorse Rd) turns right at its intersection with SC 291 (Pleasantburg Drive)
Continue south on US 25 for approximately 3 miles
Left on Ashmore Bridge Rd (just before you reach I-185, CVS Pharmacy on the corner)
Right on Augusta Arbor Way (at the first intersection)
St John is one block on the left

Traveling US 25 North (Augusta Road)
(from Aiken/Augusta/Greenwood)

Right on Ashmore Bridge Rd (at the first light beyond I-185, CVS on the corner)
Right on Augusta Arbor Way (at the first intersection)
St John is one block on the left